Recently, the research team of Professor Sun Yue of the College of Chemistry and Materials Science, SCUN has made important progress in the field of “integration of medical diagnosis and treatment”. The article entitled Melanin-dot–mediated delivery of metallacycle for NIR-II/photoacoustic dual-modal imaging-guided chemo-photothermal synergistic therapy is published on the Proceedings of the National Academy of Sciences (Proc. Natl. Acad. Sci. USA, 2019, 116, 16729-16735). PNAS is one of the world's four recognized journals. It covers the fields of medicine, chemistry, biology and physics. It is a century-old classic journal and a journal of Nature Index.
In recent years, developing new nano-probes to achieve integration of cancer diagnosis and treatment has become an important research topic in the field of biomaterials. In view of the limitations of nano-probes, such as poor light stability and limited tissue penetration capabilities, the research incorporates discrete Pt(II) metallacycle 2 and fluorescent dye 3 (emission wavelength in the second near-infrared channel [NIR-II]) into melanin dots and successfully constructed nanomaterials with dual-modal imaging and chemo-photothermal properties (as shown below). Experiments show that the nanomaterial has good solubility, biocompatibility and stability in vivo; In vivo photoacoustic imaging and NIR-II fluorescence imaging showed that the material can effectively accumulate in the tumor site, and has a good signal-to-background ratio and biodistribution; Under the guidance of dual-modal imaging, the material can achieve better anti-tumor effect through chemo-photothermal synergistic therapy with low side effects. This study provides a reference for the development of precise and controlled release of targeted anti-tumor drugs and accurate monitoring of tumor development. It also provides a more accurate means of biopsy analysis for translating targeting anti-tumor drugs from laboratory to clinical application.
Article from Prof. Sun Yue of the College of Chemistry and Materials Science published on PNAS.
Image: College of Chemistry and Materials Science
The article is the result of the cooperation between Professor Sun Yue and Professor Peter J. Stang of the University of Utah, and Professor Sun Yao of Huazhong Normal University. SCUN is the first author affiliation, Professor Sun Yue and Ding Feng from Huazhong Normal University are the first authors.
(Editor: Liu Hong; Source: College of Chemistry and Materials Science, Science and Technology Development Institute)